Increase in increments of 500 mg twice a day every 2 weeks based on efficacy and tolerability. The adverse reactions that result from keppra injection use include all of those reported for keppra tablets and oral solution. Levetiracetam in sodium chloride injection levetiracetam in. Keppra is indicated as monotherapy in the treatment. Apr 15, 2018 levetiracetam is an anticonvulsant for partial, myoclonic, and primary generalized tonicclonic seizures. Drug alerts and fda news american epilepsy society. Levetiracetam injection fda prescribing information. Specifically, pharmacists have access to drug information from a variety of resources, including print publications, subscriptionbased electronic databases e. No seizures or graft rejections were observed in the study population. New warnings include behavioral abnormalities and psychotic symptoms, somnolence and fatigue, red blood cell and white blood cell count decreases, as well as significant diastolic blood pressure. These highlights do not include all the information needed. Dec 04, 20 intravenous levetiracetam iv lev, a second generation anticonvulsant, is approved by the fda as an adjunctive treatment in patients 16 years or older when oral administration is not available.
Levetiracetam injection fda prescribing information, side. Do not donate blood, organs, tissues and cells for transplantation. Preparation and administration of keppra injection. Equivalent doses of intravenous iv levetiracetam and oral levetiracetam result in equivalent c max, c min, and total systemic exposure to levetiracetam when the iv levetiracetam is administered as a 15minute infusion. This document is commonly known as a package insert because it is usually included with each package of the medicine. Clinical pharmacology and pharmacokinetics of levetiracetam. This information does not take the place of talking to your healthcare provider about your medical condition or treatment. See full prescribing information for levetiracetam injection. Yescarta is a cd19directed genetically modified autologous t cell immunotherapy indicated for the treatment of. This dose reduction will lower the likelihood of hypoglycemia see warnings and precautions 5. The freezedried powder should be reconstituted with 5 ml of 0. Levetiracetam is an senantiomer of the ethyl analog of piracetam, in the class of nootropic drugs which are considered to be pharmacologically safe 2, 3.
Conversion to or from oral to intravenous administration can be done directly without titration. Highlights of prescribing information these highlights do not include all the information needed to use levetiracetam injection safely and effectively. Lantus, the recommended initial lantus dose is 80% of the toujeo dose that is being discontinued. One vial of levetiracetam injection contains 500 mg levetiracetam 500 mg5 ml. The total daily dose and frequency of administration should be maintained. Levetiracetam in sodium chloride injection safely and effectively. Levetiracetam is an anticonvulsant for partial, myoclonic, and primary generalized tonicclonic seizures. Oct 30, 2019 each ml contains 100 mg of levetiracetam.
Our products are available from authorized distributors. Levetiracetam can also be given by csci diluted with either water for injection or sodium chloride 0. Levetiracetam injection should be administered as a 15minute iv infusion. Levetiracetam injection was found to be physically compatible and chemically stable when mixed with. Levetiracetam for the prevention of busulfaninduced seizures. Medication guide levetiracetam tablets 250 mg, 500 mg. Patients in the comparator group received conventional amphotericin b as a slow infusion at a daily dose of 1. These highlights do not include all the information needed to use vimpat safely and effectively.
The content on this site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. One vial of keppra injection contains 500 mg levetiracetam 500 mg5 ml. Full prescribing information 1 indications and usage zofran is indicated for the prevention of nausea and vomiting associated with. Elepsia xr contains levetiracetam, an antiepileptic drug, as extendedrelease tablets for oral administration. Nov 04, 2019 the adverse reactions that result from keppra injection use include all of those reported for keppra tablets and oral solution. Lidocaine hydrochloride injection, usp is a sterile, nonpyrogenic solution of an antiarrhythmic agent administered intravenously by either direct injection or continuous infusion. Levetiracetam journal of pain and symptom management. Highlights of prescribing information these highlights do not. One relapse, one case of sinusoidal obstruction syndrome, and two deaths occurred in the levetiracetam group, while no relapses, two cases of sinusoidal obstruction syndrome. A vast amount of practicerelated information is available to todays healthcare practitioner. Levetiracetam in sodium chloride injection, for intravenous use initial u. Keppra is an antiepileptic drug available as 250 mg blue, 500 mg yellow, 750 mg orange, and mg white tablets and as a clear, colorless, grapeflavored liquid 100 mgml for oral administration. Concentrate for solution for infusion sterile concentrate. If changing from a treatment regimen with an intermediate or longacting insulin to a.
For complete ordering information, please contact your local pharmaceutical distributor. The chemical name of levetiracetam, a single enantiomer, is s. Find patient medical information for levetiracetam intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. An iv formulation of levetiracetam is available for those unable to take oral preparations and appears to have an excellent safety profile including rapid iv use in children 16,17,20,21,2324. Evidence defining compatibility of levetiracetam with cardiovascular agents is needed for patient safety. It is structurally unrelated to any other antiepileptic class and has a novel mechanism of action. These highlights do not include all the information needed to. Keppra injection is for intravenous use only and should be diluted in 100 ml of a compatible diluent prior to administration. Serious infections and malignancies 1 indications and usage 1. Currently, intravenous iv levetiracetam lev is approved only as an alternative or replacement therapy for patients unable to take the oral form of this antiepileptic drug aed. Vimpat lacosamide film coated tablet, for oral use, cv. Feb 01, 2020 levetiracetam injection should be administered as a 15minute iv infusion. Patients using lantus vials must never reuse or share needles or syringes with another person. Physical compatibility of levetiracetam injection with.
Briviact had no added therapeutic benefit when coadministered with levetiracetam. Sections or subsections omitted from the full prescribing information are not listed. Mylan manufactures levetiracetam in sodium chloride injection levetiracetam in sodium chloride in strengths of 500 mg100 ml 5 mgml in 082 sodium chloride injection mg100 ml 10 mgml in 075 sodium chloride injection1500 mg100 ml 15 mgml in 054 sodium chloride injection. Medication guide levetiracetam tablets 250 mg, 500 mg, 750 mg, mg read this medication guide before you start taking levetiractem and each time you get a refill. It is available in various concentrations with the following characteristics. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for keppra levetiracetam. Dailymed keppra levetiracetam injection, solution, concentrate. Keppra levetiracetam rx only 250 mg, 500 mg, 750 mg, and. Keppra injection is for intravenous use only and must be diluted prior to administration. Levetiracetam in sodium chloride injection is an antiepileptic drug indicated for adult patients 16 years and older when oral administration is temporarily not feasible. After iv voriconazole therapy, the median duration of po voriconazole therapy was 76 days range 2232 days. Although unauthorized, levetiracetam is also used for status epilepticus refractory to benzodiazepines, generally in a dose of 2030mgkg given as a single iv bolus. Efficacy appears comparable to fosphenytoin, phenytoin and valproate. Sharing poses a risk for transmission of bloodborne pathogens.
Aug 23, 20 currently, intravenous iv levetiracetam lev is approved only as an alternative or replacement therapy for patients unable to take the oral form of this antiepileptic drug aed. Serving faculty and staff in norman, oklahoma city, and tulsa campuses. It belongs to a class of drugs known as anticonvulsants. Levetiracetam therapy can be initiated with either intravenous or oral administration. See full prescribing information for levetiracetam in sodium chloride injection. Keppra levetiracetam rx only 250 mg, 500 mg, 750 mg, and mg tablets 100 mgml oral solution description. See table 1 for the recommended preparation and administration of keppra injection to achieve a dose of 500 mg, mg, or 1500 mg.
Levetiracetam for the prevention of busulfaninduced. Nine patients 45% received levetiracetam and 11 55% received phenytoin for seizure prophylaxis. Levetiracetam glaxosmithklineotsuka pharmaceuticalsucb. Monotherapy for adults and adolescents from 16years of age. It is supplied in singleuse 5 ml vials, available in cartons of 10 vials ndc 5047400263. Highlights of prescribing information hyperglycemia or.
Levetiracetam levetiracetam injection, solution hospira, inc. Levetiracetam injection may be mixed with the following diluents and antiepileptic drugs and may be stored in polyvinyl chloride pvc bags. On this page about levetiracetam iv hospira you will find information relating to side effects, age restrictions, food interactions, whether the medicine is available at a government subsidised price on the pharmaceutical benefits scheme pbs as well as other useful information. Withdraw 5 ml of the reconstituted solution and administer as an intravenous injection over no less than 3 minutes. Data have shown that it has a unique mechanism of action, linear pharmacokinetics and no known drug interactions with other anticonvulsants. Vimpat lacosamide injection, for intravenous use, cv. Levetiracetam package insert in the united states, companies that manufacture medicines are required to publish certain kinds of information about each product. Keppra levetiracetam 500 mg5 ml injection is a clear, colorless, sterile solution. Levetiracetam in sodium chloride injection premixed bag. Levetiracetam may decrease the number of seizures you have. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease.